Sim, mas é muito improvável.
Tentar atingir um local específico em uma criatura requer as regras variantes para chamados de tiros ( Ultimate Combat p.193). Que até especificam como eles interagem com vampiros e ciclopes.
A called shot is an attack aimed at a particular part of the body, in the hope of gaining some extra effect from the attack. The smaller or better guarded the area, the more difficult the called shot. A called shot is a single attack made as a full-round action, and thus can’t be combined with a charge, feats like Vital Strike, or multiple attacks with a full-attack action.
Some effects in the game, like true strike or the flash of insight ability of cyclopes, provide automatic or nearly automatic hits. Using such an ability on a called shot turns it into a normal attack, with none of the benefits or penalties associated with called shots. From a story perspective, this is because the effect cannot distinguish between a hit in general and a hit in a particular area, but it’s also necessary to keep the power of such abilities in line with their original intended effects. Some Game Masters may prefer a more theatrical or dangerous game in which magic can make a shot through the eye nearly certain, in which case this rule can be ignored.
The consequences of a successful called shot vary depending on whether the hit is a normal hit, a critical hit, or a debilitating blow (a hit that deals half the creature’s hit points of damage (minimum 50) or more).
Heart
Called shots to the heart are challenging (–10 penalty).
Called Shot: A called shot to the heart is just a normal hit with no extra effect.
Critical Called Shot: [...] A critical hit to the heart against a vampire made with a piercing weapon composed entirely of wood leaves the vampire impaled through the heart by the weapon if it fails its Fortitude save, with effects as described in the vampire monster details.
Debilitating Blow: [...] A debilitating blow to the heart against a vampire made with a piercing weapon made entirely of wood affects the vampire as a critical hit to the heart; for example, it still receives a Fortitude save to avoid the consequences.
Portanto, é teoricamente possível, mas você deve cumprir todos os critérios a seguir:
- Realize um único ataque como uma ação de rodada completa. (A menos que você tenha feito um feito para relaxar essa restrição.)
- Acerte recebendo -10 no teste de ataque e sem usar o Flash of Insight ou qualquer outra coisa que possa banalizar este passo.
- Obtenha um acerto crítico ou cause pelo menos 50 de dano ou metade do HP do vampiro (o que for maior).
- E finalmente o vampiro ganha um strong save. (DC = o resultado numérico de sua rolagem de ataque, ou seja, a maior CA que poderia ter atingido).