Não.
De acordo com a Enciclopédia de Dunas , os D-lobos foram criados cruzando uma gama de vivendo espécies de lobo entre si. Isso (juntamente com o desgosto inerente de Leto à engenharia genética) teria impedido o uso do extinto Direwolf como modelo:
Leto was forced to begin elsewhere. The earliest ancestors of the D-wolves were wolves imported from a dozen worlds chosen variously for speed, size, endurance and efficiency in hunting. In addition, Gaze Hounds (dogs whose visual acuity had long since made them the most popular watch animals in the Imperium; native to Centralia) were bred with the second-generation hybrids and with several of the later generations. This cross produced wolves that could perform as sight- hunters and were thus less dependent on scent-tracks which their human prey might be. able to disguise or obliterate.
Leto had originally chosen some of the largest species of wolves available to him, and he continued to increase the shoulder- height of the average litter by breeding the largest animals back into the mix. By the end of the first half-century of the program, he had succeeded in producing wolves that dwarfed all other known species.