Não.
Este artigo no Bustle , intitulado" é Leta Lestrange nos livros de Harry Potter? O Misterioso Ex de Newt é um novo personagem ", deixa isso bem claro:
In Fantastic Beasts, the Lestrange family doesn't directly appear, but it is teased that Newt Scamander had a close relationship with one Leta Lestrange (played by Zoe Kravitz). If you're like me, the second you heard that name you thought to yourself, "I don't remember a Leta Lestrange." And if you then panicked about possibly forgetting a Harry Potter detail, don't worry: Leta Lestrange is not in the Harry Potter books.
[...]
Given the fact that Leta is a new character to the Harry Potter world, there isn't much we can learn about her from the Harry Potter series, but we will be learning a whole lot more in the planned Fantastic Beasts sequel. "Leta comes into the second movie," director David Yates said at a recent press junket for Fantastic Beasts and Where to Find Them.
(emphasis mine)
Ambos os links no texto citado acima são para um segundo artigo do Bustle, que confirma que Leda [sic] Lestrange é um novo personagem criado para os filmes Fantastic Beasts .