As origens da Bene Gesserit são abordadas no prequel de Anderson / Brian Herbert " Duna: A Batalha de Corrin ".
A ordem foi iniciada por Raquella Berto-Anirul, que foi a primeira Reverenda Madre.
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Seus poderes originalmente foram causados quando ela foi infectada durante a Epidemia de Rossak, e foi tratada com água que foi infundida com plantas nativas de Rossak. Isso combinado com o vírus alterou-a para que ela tivesse controle do nível celular e pudesse controlar reações químicas em seu corpo.
Sounding apologetic, Jimmak said, "We put you in the healing water. My friends and me. Let you soak for a whole day. It washed away your fever."
"Healing water?" Raquella realized that she did feel strangely energized.
"Special place." He smiled. "Only the Misborn know it."
...
From the blood samples, he {{Dr Suk}} concluded that something peculiar had happened inside Raquella's body, a biochemical transformation he had never seen before. The battle between the retrovirus and the strange chemicals in the cenote had done something to her biochemistry, changing her in fundamental ways.
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Esses poderes se manifestaram quando a Feiticeira Suprema Ticia envenenou-a com "Droga Rossak":
She was already lost, drifting into dark unconsciousness. Suddenly light flared in her mind, showing Raquella a new way to fight back, a weapon she had not known she possessed. Her body had been altered in the crucible of the Scourge, after assimilating the incomprehensible mixture of environmental chemicals. Raquella had unexpected skills and new resources now, deep within her very cells.
Utter calmness pervaded her, and in her mind's eye Raquella saw the connections that led from the core of her brain—neural pathways spreading outward to veins, tendons, muscle—governing every function, whether voluntary or automatic. All so clear, like a human blueprint. ...
Durante este evento, ela também surgiu com o início da infame ladainha "Fear":
"I will not give up," she murmured. "I will fight back. Only fear can kill me now."
Going deep within herself, Raquella waged an internal war.
She shored up her body's defenses and constructed a biochemical wall against the poison's attack. Then she confronted the enemy head-on. Analyzing the molecular structure of the Rossak drug, she shifted the elements around...
... Because she was doing this for the first time, she explored her abilities, and realized that she had complete control over every cell and extraneous molecule in her body. ...
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Ela também foi (independentemente) a primeira pessoa que percebeu as propriedades medicinais da especiaria melange, junto com seu marido M. Suk (o fundador da escola médica Suk visto em Dune).
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Ela começou a ordem das Feiticeiras de Rossak, que tinham poderes mentais incomuns E começaram o conceito de programa de criação:
Ticia gave him a withering look for interrupting her. "...Now, in the face of this sweeping epidemic, I point out that we Sorceresses have another area of expertise. Because of our harsh world and our precise records of breeding over many generations, we understand bloodlines, the most important raw material of the human race. If this Omnius Scourge grows worse, we could lose prime branches of our species—not just the sheer casualties, but paths to our future.
"Now, as whole families, whole cities, are devastated on world after world, we cannot react too soon or too vigorously. Our race is in extreme peril. Even as we struggle to find a cure for this foul biological weapon, we must also take drastic action to preserve the best DNA before it it lost forever—protect and store key markers of some of the strongest lines, or the disease may erase them entirely. We must establish a program to protect the genetic information of all people, on all planets." She lifted her chin. "We Sorceresses have the capacity to manage such a program."