Não, você só precisa fornecer o itinerário para sua primeira viagem, além de justificar por que você precisa de um visto para múltiplas entradas. Por exemplo. veja o que o Consulado da República Tcheca em Teerã diz sobre vistos de múltiplas entradas:
Multiple-entry visas may be issued with a period of validity between six months and five years, where the following conditions are met:
(a) The applicant proves the need or justifies the intention to travel frequently and/or regularly, in particular due to his occupational or family status, such as business persons, civil servants engaged in regular official contacts with Member States, and EU institutions, representatives of civil society organisations travelling for the purpose of educational training, seminars and conferences, family members of citizens of the Union, family members of third-country nationals legally residing in Member States and seafarers; and
(b) The applicant proves his integrity and reliability, in particular the lawful use of previous uniform visas or visas with limited territorial validity, his economic situation in the country of origin and his genuine intention to leave the territory of the Member States before the expiry of the visa applied for.
Caso contrário, os requisitos para solicitar um visto de múltiplas entradas são exatamente os mesmos.