Sim, o coronel Mustang rasga a pedra filosofal diretamente de seu peito:
Mas enquanto ele segura a pedra em sua mão, ela reforma em torno da pedra os pedaços de carne ainda na pedra.
A homunculus can be truly destroyed ONLY when their Philosopher's stone has been exhausted AND their body is destroyed. The stone that powers a homunculus is comprised of the lifeforces of the victims that died in its creation. So each time a homunculus take damage equal to a fatal injury, a bit of lifeforce is lost as they regenerate said damage. This is why a battle with a homunculus goes bad for most humans, it is simply too difficult to deal out enough damage against the homunculus before the human is overwhelmed.