Spoilers para os Vingadores: Era de Ultron e a segunda temporada de Agentes da SHIELD abaixo.
Nós aprendemos no episódio Agents of SHIELD "The Dirty Half Dozen" que;
It is Director Coulson that informs Maria Hill of the location of Baron von Strucker, Dr. List and Loki's Sceptre, which sets the events of Avengers: Age of Ultron in motion.
O próximo episódio "Scars" nos mostra isso;
The Helicarrier seen in Avengers: Age of Ultron during the evacuation of Sokovia was supplied by Director Coulson under something known as Theta Protocol.
Esses dois eventos são uma prova clara de que, no universo, os eventos dos Agentes da SHIELD importam para o resto do universo cinematográfico da Marvel (fora do universo, é mais do que provável que o programa de TV é simplesmente encontrar maneiras de fazer parte de uma imagem mais ampla dos filmes).
Também no Agentes da SHIELD season 2 finale "S.O.S";
We see that the faux-Terrigen Crystals created by Jiaying are dissolving in the sea, infecting fish that are swimming close by. These fish are then caught by fisherman and turned into Omega 3 Fish Oil pills. We know that if any latent Inhumans swallow these pills, their powers will be activated - potentially creating a sudden influx of powered people in the Marvel Cinematic Universe, which could form the basis for the upcoming Captain America: Civil War film.