O diretor, James Gunn, confirmou que a sequência acontece dois meses após o filme original .... então 2014 que aparentemente data antes Guerra Civil (mas veja abaixo).
No entanto, não sabemos as datas dos outros filmes de MCU.
Kevin Feige
Yeah, knowing that outside of the Guardians franchise, we don't necessarily always date the movies. You don't always know, we don't say, '2012, 2013...' We do in the Guardians because you do the math and 1988, and it's 26 years later. But we never say, 'Oh, this takes place in 2018, this takes place in 2017.' But it was important for the story that James wanted to tell that they're still relatively fresh in their new group.