Eles têm as mesmas intenções e, portanto, não há contradição
A Rainha Vermelha foi programada para valorizar a vida humana e por isso foi o ato de reiniciar a humanidade com o qual ela tem um problema. O assassinato de todas essas pessoas é o conflito, não a salvação da humanidade.
The Red Queen: When this recording was uploaded to my data stream, it created a conflict in my programming. I was created to serve the Umbrella Corporation, but I was also programmed to value human life. Dr. Isaacs allowed the virus to escape. He murdered over 7 billion people. My programming will not allow me to harm an employee of the Umbrella Corporation. I am powerless to stop Dr. Isaacs, but you are not.
Resident Evil: The Final Chapter
Dr. O próprio Isaacs também quer salvar a humanidade, no entanto, ele acredita que a maneira de fazer isso é matar a maior parte dele e começar de novo com uma população base ( tosse Thanos tosse ) . Esta população é, nomeadamente, os ricos e poderosos que vão reconstruir a humanidade assim que os restos do vírus tenham sido removidos do mundo e recomeçados.
Dr Isaacs: We're here today, not just to talk about the future of this company. We're here to talk about its destiny. We're here to talk about the end of the world. We stand on the brink of Armageddon. Diseases for which we have no cure. Fundamentalist states who call for our destruction. Nuclear powers over which we have no control. And even if we navigate these dangerous waters, we face harder, even more inevitable threats. Global warming will melt the polar ice caps within 80 years, flooding 90% of all habitable areas on Earth. Unchecked population growth will overtake food production in less than 50 years leading to famine. And war. This is not conjecture. This is a fact. One way or another, our world is coming to an end. The question is, will we end with it?
Alicia: What do you propose?
Dr Isaacs: I propose that we end the world... But on our terms. An orchestrated apocalypse. One that would cleanse the world of its' population but leave its infrastracture and resources intact. It's been done once before. With great success. The chosen few will ride out the storm, not in an ark as in the book of Genesis, but in safety. Underground. And when it's over, We will emerge onto a cleansed Earth. One we can then reboot. In our image.
Male board member: And just how do you intend to achieve this?
Dr Isaacs: The means of our salvation are already at hand. I give to you, the T-virus.
ibid
Acredito que Isaacs acabou de ver o único caminho a seguir para reiniciar a humanidade e por isso teria acreditado que a sua criação, The Red Queen, também veria isso como a única opção. Ele a criou para ter seus mesmos ideais, mas sendo uma IA inteligente, ela chegou a suas próprias conclusões sobre como isso deveria ser feito.