Um acidente notável foi o Helios Airways voo 522 acidente, onde o sistema de pressurização foi desligado e os pilotos ignoraram a buzina de aviso, porque acharam que era o aviso de configuração da decolagem. De Wikipedia página:
As the aircraft climbed, the pressure inside the cabin gradually decreased. As it passed through an altitude of 12,040 feet (3,670 m), the cabin altitude warning horn sounded. The warning should have prompted the crew to stop climbing, but it was misidentified by the crew as a take-off configuration warning, which signals that the aircraft is not ready for take-off, and can only sound on the ground.
O relatório oficial de acidentes explica a fonte da confusão em mais detalhes (ênfase minha):
The Board examined the flight crew’s actions to disengage the autopilot and auto-throttle,
and to retard the throttles upon onset of the warning horn. Given that the expected
reaction to a cabin altitude warning horn would have been to stop the climb (there was no
evidence to this effect), the Board considered such actions to signify that the flight crew
reacted to the warning horn as if it had been a Takeoff Configuration Warning (the two
failures use the same warning horn sound). [...]
The warning horn was designed to signal two distinctly different situations. The Board
considered the role of experience in interpreting and reacting to the warning horn. In the
course of his career, a pilot is generally likely to only hear the warning horn when it is
associated with a takeoff and a takeoff configuration problem. [...]
Most pilots are not very likely to experience a cabin pressurization problem and the
associated warning horn at any time during their line flying.
Conclusão: Nunca use o mesmo aviso para várias situações, se os pilotos se acostumarem apenas a um deles, caso contrário eles ignorarão o aviso para as outras situações!