De acordo com o ator do personagem, Jim Parsons, a resposta é um "não" confiante, mas ele admite alegremente (e falou extensivamente sobre) as características de "aspergerismo" de Sheldon.
JP: When I was first asked about it, I literally hadn’t… Well, I’d heard of the disease. Do they call it a disease? I don’t want to be…
AVC: A disorder.
JP: Disorder, thank you. How ridiculous now, looking back, that I said that. I’d heard of the disorder but I didn’t know what it was at all. And when I asked the writers if Sheldon had Asperger’s, they said, “No, he does not. That’s not what we’re doing.” - AVC Interview
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Q. As the show’s gotten bigger, you’ve been adopted by more than one community. Rather than say “Hey, do you want to be a spokesman for, you know, Pepsi and we’ll pay you X?” people say, “You are now the spokesman for Asperger’s.” How do you deal with that?
JP: Asperger’s came up as a question within the first few episodes. I got asked about it by a reporter, and I had heard of it, but I didn’t know what it was, specifically. So I asked the writers—I said, “They’re asking me if Sheldon has Asperger’s,” and they were like, “No.” And I said, “OK.” And I went back and I said, “No.” And then I read some about it and I went, OK, well, if the writers say he doesn’t, then he doesn’t, but he certainly shares some qualities with those who do. I like the way it’s handled. - Adweek Interview
Da mesma forma, os co-criadores do programa, Chuck Lorre e Bill Prady, indicou que, do ponto de vista da escrita, a decisão foi tomada não tê-lo positivamente indicado como tendo uma condição específica porque isso tornaria mais fácil para eles mudarem de caráter se precisassem para:
"We chose not to diagnose Sheldon," says "Big Bang" co-creator Chuck Lorre.
"Big Bang" co-creator, Bill Prady, who based Sheldon on computer programmers he used to work with, has said they were afraid that if they labeled Sheldon an Aspie, they would have too much responsibility to depict the condition accurately within a sitcom. - NJ.com
Prady também declarou em uma entrevista com o Slate que as peculiaridades de Sheldon são exclusivamente " Sheldony " sem necessariamente fazer parte de uma condição mais ampla.
"I just think of his actions as 'Sheldony.' Some things feel instinctively correct for his character," says Prady, who recalls one software colleague who couldn't go anywhere alone that he hadn't been to before. "He'd say, 'I can't go to 47th Street Photo by myself.' And it was maybe three blocks away. It was never questioned. Quirks were never challenged—they were simply accepted as a quality of the person."
"Are these things Asperger's?" he asks. "I don't know."