Nunca há qualquer resposta dada no programa para isso, mas como Seth MacFarlaine parece se divertir com o humor depreciativo, é natural que um personagem seja um alvo fácil.
Mila Kunis estava citado como dizendo ;
"She's the scapegoat," Kunis described her cartoon character. "Meg gets picked on a lot. But it's funny. It's like the middle child. She is constantly in the state of being an awkward 14-year-old, when you're kind of going through puberty and what-not. She's just in perpetual mode of humiliation. And it's fun."