Infelizmente não , de acordo com o Wikitravel.
There is no road or rail system. The easiest way to get around Greenland is by plane, particularly Air Greenland. In the summer, Arctic Umiaq Line passenger ships provide service to destinations between Narsarsuaq and Uummannaq along the west coast.
Claro, se você tem um skidoo ou trenó de cachorro, você pode fazer o seu próprio caminho;)
A Wikipédia tem mais informações - Transporte na Groenlândia
The transportation system in Greenland is very unusual in that Greenland has no railways, no inland waterways, and virtually no roads between towns.
Ele entra em mais detalhes sobre as poucas estradas que existem:
There are 150 km (90 mi) of roads in the whole country; 60 km (40 mi) of the roads are paved. Two towns are connected by a 4.5 km road, Ivittuut and Kangilinnguit; the rest are isolated.