Basicamente, tudo o que é normal é seguro.
Há um cogumelo que fica tóxico se combinado com álcool, mas o álcool em si não é 100% seguro e se você está colhendo cogumelos silvestres você precisa estar consciente da segurança, então não é algo que você pode encontrar acidentalmente ou com ingredientes storebought.
Parágrafo relevante de Wikipedia
Consuming Coprinopsis atramentaria within a few hours of alcohol results in a "disulfiram syndrome". This interaction has only been known since the early part of the twentieth century. Symptoms include facial reddening, nausea, vomiting, malaise, agitation, palpitations and tingling in limbs, and arise five to ten minutes after consumption of alcohol. If no more alcohol is consumed, they will generally subside over two or three hours. Symptom severity is proportional to the amount of alcohol consumed, becoming evident when blood alcohol concentration reaches 5 mg/dL, and prominent at concentrations of 50–100 mg/dL. Disulfiram has, however, been known to cause myocardial infarction (heart attack). The symptoms can occur if even a small amount of alcohol is consumed up to three days after eating the mushrooms, although they are milder as more time passes. Rarely, a cardiac arrhythmia, such as atrial fibrillation on top of supraventricular tachycardia, may develop.