Não. Não faz parte do universo cinematográfico da Marvel
Em uma entrevista com o Total Film , o diretor do filme disse
"Very early on, when we were collaborating with Marvel, the decision was made to intentionally not connect it to the Marvel universe," director Don Hall told Total Film. "Everybody felt like it would be great for us to take this idea of theirs and make our own universe with it. Marvel really encouraged us to do that. So there'll be no Iron Man or Captain America, and no Avengers in this world. Our Avengers are the Big Hero 6."
John Lasseter também disse que o filme foi feito 100% independente dos quadrinhos.
“Not yet. No, we haven’t,” admitted Lasseter. “If we went directly into the Marvel Universe, that would mean we’d work more directly with Marvel,” and aside from some screenings that involved Joe Quesada, Marvel Entertainment’s chief creative officer, Big Hero 6 was a Disney project through and through. “Without question, it was made 100 percent here,” said Lasseter. “They’d forgotten the books existed.”